Brucella abortus is an intracellular pathogen that shares several common features with C. crescentus such as an asymmetric cell division and regulatory pathways controlling cell cycle and differentiation. Moreover the cell cycle is tightly controlled during infection of host cells and metabolism plays a crucial role in Brucella virulence. Our studies on B. abortus aim at understanding how metabolism and cell cycle are coordinated during intracellular invasion.
Acinetobacter baumannii is an opportunsitic pathogen classified by the WHO as a critical MDR-bacterium armed with many mechanisms allowing to resist to most of antibiotics. We study the the impact of the alarmone (p)ppGpp on the cell cycle, metabolism, antibiotic resistance/tolerance and virulence of A. baumannii.