• Eric Muraille's Research Group
  • Eric Muraille's Research Group
  • Eric Muraille's Research Group

Eric Muraille

Main topics

Despite many advances, infectious diseases remain the major causes of morbidity and mortality in much of the world. The goal of our research group is to improve our fine understanding of the factors that orchestrate antimicrobial host protective immune responses in vivo.

 

We are working on several different aspects at the interface between the host and Brucella, the bacteria responsible of brucellosis, a worldwide zoonosis. Our main objectives are:

(i) the development and characterization of new more physiological experimental models of Brucella infection in mice (such as intranasal and intradermal infection models)

(ii) the characterization of Brucella reservoir cells in vivo

(iii) the identification of immune effectors implicated in the control of primary and secondary infections

(iv) the identification of bacterial genes specifically required to escape the immune response

 

Our research works are interdisciplinary (immunology, microbiology) and involve a close cooperation between the Université Libre de Bruxelles (ULB) (animal facility, immunohistofluorescent microscopic analysis) and Université de Namur (UNamur) (flow cytometry analysis, Biosafety Level 3 laboratory).

 

Selected recent publications

 

Student training

During the master thesis and the thesis, students are trained in the following techniques:

- in vitro and in vivo Brucella infectious models

- murine experimental model

- manipulation in biosafety level III (BL-3) laboratory

- flow cytometry analysis (FACS) (FACSCalibur and FACSVerse)

- immunohistofluorescence analysis

- ELISA, PCR

 

Current scientific collaborations

Xavier De Bolle, Université de Namur

Jean-Jacques Letesson, Université de Namur

Laurence Van Melderen, Université Libre de Bruxelles

Jean-Marie Vanderwinden, Université Libre de Bruxelles

Jean-Paul Coutelier, Université Catholique de Louvain

Fabrice Bureau, Université de Liège

Marta Romano, Institut scientifique de Santé Publique (WIV-ISP)

Olivier Denis, Institut scientifique de Santé Publique (WIV-ISP)